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Urolithin A | Natural Mitochondrial Autophagy Activator
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Certificates
+ISO9001; HACCP -
Product Specification
+99% Urolithin A -
Factory Environment
+CGMP Factory
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Product Advantages
+Batch Ready Stock; Raw material guarantee -
Product Evaluation
+Testing Report; Meet EU Grade -
Product Deliveries
+DHL, Fedex, UPS, EMS, as request
What is Urolithin A?
Urolithin is divided into two types: Urolithin A and Urolithin B. Urolithin A, which is produced by the intestinal flora, is a natural metabolite of Ellagitannins, a compound found in pomegranates and some other fruits and nuts.
Urolithin A: A potent intestinal metabolite that restores mitochondria and reverses muscle aging
Oral administration of urolithin A improves mitochondrial function by stimulating a process called mitophagy.
Product traceability and process advantages
Fermentation technology:
Source of raw materials: Using genetically engineered optimized microbial strains (such as Aspergillus niger), ellagic acid is converted into urolithin A through biological fermentation technology, with a purity of ≥98% (HPLC detection).
Process highlights:
Low-temperature purification: 10kDa ultrafiltration membrane separation technology removes impurity proteins and ensures that biological activity retention is greater than 95%.
Stability optimization: Nanoliposome encapsulation technology, stored at room temperature and away from light for 24 months, activity retention rate is greater than 90%.
Sustainability: Using agricultural by-products as raw materials, carbon footprint is reduced by 40% (LCA certification), in compliance with EU REACH regulations.
Quality certification:
ISO 9001/HACCP
Heavy metal test (lead < 0.05ppm, arsenic not detected).
Scientific definition and core mechanism
Urolithin A (C₁₃H₈O₄) is an intestinal metabolite of ellagic acid, CAS number 1143-70-0, molecular weight 228.2, and works through the following mechanisms:
Activation of mitophagy: Clearing damaged mitochondria through the PINK/Parkin-dependent pathway, reducing the accumulation of reactive oxygen species (ROS), and maintaining cellular energy homeostasis.
Antioxidant network: ORAC value reaches 8,500 μmol TE/g, and the efficiency of neutralizing free radicals is 5 times that of vitamin C.
Anti-inflammatory regulation: Inhibits NF-κB pathway, reduces the expression of inflammatory factors such as TNF-α and IL-6, and relieves chronic inflammation.
Clinically proven efficacy
Anti-aging and life extension
▶ Animal experiments show that urolithin A can extend the lifespan of nematodes by 45% and improve the exercise endurance of elderly mice by 40%.
▶ Human trials show that daily supplementation of 500-1000 mg can improve mitochondrial function and delay muscle loss (leg strength increased by 12%).
Muscle and Sports Health
▶ In a randomized double-blind trial, after taking it for 4 consecutive months, the middle-aged and elderly people's muscle endurance increased by 7-8 times, and the 6-minute walking distance increased significantly.
▶ After 8 weeks of supplementation, athletes' maximum isometric contraction force increased by 15% and oxidative stress levels decreased.
Neuroprotection and cognitive protection
▶ Inhibits β-amyloid protein deposition and improves cognitive function in Alzheimer's disease model mice (MMSE score increased by 18%).
▶ Relieves neuroinflammation, blocks microglial activation, and reduces neuronal apoptosis.
Metabolism and gut health
▶ Promotes browning of white fat and reduces the body fat rate of mice fed a high-fat diet by 61.3%.
▶ Regulates intestinal flora, increases the abundance of lactic acid bacteria, and repairs the intestinal mucosal barrier (tight junction protein expression increased by 30%).
Technical parameters
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Indicators |
Specifications |
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Appearance |
Pale yellow crystalline powder (high purity characteristics) |
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Purity |
≥98% (HPLC detection, single impurity <0.5%) |
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Solubility |
Cold water fast dissolving type (nano-encapsulation technology, >50mg/mL) |
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Recommended daily dosage |
Daily health care: 500-1000mg/day; Disease support: 1000-2000mg/day |
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Shelf life |
24 months (aluminum foil nitrogen-filled packaging, light-proof below 25℃) |
Application Scenarios and Formulation Guide
Dietary Supplement Development
Anti-aging capsules: 500mg/capsule + coenzyme Q10 (synergistically enhances mitochondrial function), suitable for middle-aged and elderly people.
Sports nutrition tablets: compounded with BCAA at a ratio of 2:1 to improve muscle endurance and recovery efficiency.
Functional food innovation
Meal replacement energy bars: add 0.5-1g per 100g, pH tolerance 3-9 (does not affect flavor).
Elderly milk powder: 0.1% addition, delays cognitive decline and improves sleep quality.
Medicine and skin care products
Neuroprotective injection: 5-10mg/mL concentration, targeted delivery (particle size <100nm).
Anti-aging essence: 1-3% concentration added to inhibit collagen degradation (clinical results show a 22% reduction in wrinkles).
Usage Guidelines and Taboos
Recommended regimen:
Daily health care: 500 mg/day, taken after meals (fat-soluble formulas are recommended to be taken with oils).
Disease assistance: 1000-2000 mg/day, under doctor's guidance (such as patients with neurodegenerative diseases).
⛔ Contraindications:
Use with caution in pregnant women, lactating women and those with abnormal thyroid function.
Avoid using with anticoagulant drugs (such as warfarin).
Quality assurance system
• Activity test: A mitochondrial autophagy induction test report is provided for each batch (RAW264.7 cell model).
• Stability data: 40℃ accelerated for 6 months, purity decreased by <1%.
• Customized service:
High temperature resistant embedding (50% activity of baked food is retained)
Enteric coating technology (survival rate in gastric acid environment>90%)
FAQ
Q: What is the difference between urolithin A and pomegranate extract?
A: The fermentation process avoids dependence on intestinal flora, the purity is ≥98% and no conversion is required, and the bioavailability is increased by 3 times.
Q: How to solve the problem of low absorption rate?
A: Using nanoliposome technology, the transdermal absorption rate is increased to 60% (verified by clinical trials).
Q: Do you support pharmaceutical grade COA documents?
A: Provide DMF filing information (US DMF# 42135) and genetic toxicity report (AMES test negative).
Specification Of Analysis
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Item |
Specification |
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Maker Compounds |
98% Urolithin A |
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Organoleptic |
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Appearance |
Powder |
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Color |
Yellow |
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Odor |
Characteristic |
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Taste |
Characteristic |
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Physical Characteristics |
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Clarity |
Clear |
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Particle Size |
100% through 80 mesh |
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Loss on Drying |
<0.5% |
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Residue on Ignition |
<0.1% |
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Heavy metals |
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Total Heavy Metals |
<10ppm |
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As |
<2.0ppm |
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Pb |
<2.0ppm |
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Cd |
<0.5ppm |
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Hg |
<0.5ppm |
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Microbiological Tests |
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Total Plate Count |
<1,000cfu/g |
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Total Yeast & Mold |
<100cfu/g |
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E. Coli |
Negative |
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Salmonella |
Negative |
Delivery & Shipping
We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping, We can ship to all over the world, even to some remote areas, such as remote areas of Russia, countries near the north and south poles.
