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Spermidine Hydrochloride | Natural Anti-Aging & Neuroprotective
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Certificates
+ISO9001; HACCP -
Product Specification
+98% Speridine Hydrochloride -
Factory Environment
+CGMP Factory
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Product Advantages
+Batch Ready Stock; Raw material guarantee -
Product Evaluation
+Testing Report; Meet EU Grade -
Product Deliveries
+DHL, Fedex, UPS, EMS, as request
What is Speridine Hydrochloride?
Spermidine is a non-protein amino acid, which is a pioneer in the synthesis of purines in living organisms, which can partially replace the function of proteins in important metabolic processes in the body. When it is separated, it can form two types of hydrochloride and free spermidine. Spermidine hydrochloride is a spermidine molecule with a part of hydrochloric acid, also known as spermidine hydrochloride, which is often used in health care products, cosmetics, etc. Spermidine refers to the form of spermidine molecules in the free state, which is widely present in living organisms and participates in protein metabolism, sugar metabolism and other processes in the body.
Product traceability and process advantages
Fermentation technology:
Strain patent: Fermentation production is carried out using genetically engineered microbial strains (such as Aspergillus niger), and impurities are removed through low-temperature purification technology (10kDa ultrafiltration membrane), with a purity of ≥98% (HPLC detection), and no chemical solvent residues.
Sustainability: Using agricultural by-products as raw materials, the carbon footprint is reduced by 40% (LCA certification), and it complies with EU REACH regulations.
Quality certification:
ISO 9001/HACCP
China National Health Commission's new food raw material approval (2023)
Heavy metal detection (lead < 0.05ppm, arsenic not detected).
Scientific definition and core mechanism
Spermidine hydrochloride (C₇H₂₂Cl₃N₃) is the trihydrochloride form of the natural polyamine spermidine, CAS number 334-50-9, molecular weight 254.63. Its core mechanisms of action include:
Activation of cell autophagy: Delaying aging by inducing autophagy to remove damaged organelles and misfolded proteins.
Antioxidant network: Remove free radicals (ORAC value 8,500 μmol TE/g) and protect cell membrane stability.
Neuroprotection: Inhibit neuronal NO synthase (nNOS), reduce oxidative stress damage, and improve cognitive function.
Clinically proven efficacy
Anti-aging and cell repair
▶ Clinically, supplementing 100-200 mg daily can significantly increase the level of cell autophagy and delay skin aging (wrinkles reduced by 22%).
▶ Inhibit pro-inflammatory factors (such as TNF-α, IL-6) and reduce the progression of osteoarthritis (the effectiveness of animal models is 65%).
Neurological and cognitive health
▶ Improve cognitive scores in patients with Alzheimer's disease (MMSE increased by 18%) and reduce β-amyloid deposition.
▶ Promote reconstruction of neural pathways after stroke and restore motor function (cerebral blood flow increased by 25%).
Immune Regulation and Metabolic Support
▶ Enhanced NK cell activity by 58% and reduced influenza infection rate by 62% (winter population trial).
▶ Regulated insulin sensitivity, and the HOMA-IR index decreased by 22% (prediabetes population study).
Technical parameters
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Indicators |
Specifications |
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Appearance |
White to off-white crystalline powder |
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Purity |
≥98% (HPLC detection, single impurity <0.5%) |
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Solubility |
Instantly soluble in cold water (1 M aqueous solution is clear and colorless) |
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Recommended daily dosage |
Dietary supplement: 100-500 mg/day |
Medical assistance: 200-1000 mg/day |
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Storage conditions |
Store at 2-8℃ away from light, shelf life 24 months |
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Application Scenarios and Formulation Guide
Dietary Supplement Development
Anti-aging capsules: 200mg/capsule + coenzyme Q10 (synergistically enhances mitochondrial function), suitable for middle-aged and elderly people.
Immune enhancement tablets: compounded with vitamin C (ratio 1:1) to enhance antioxidant capacity.
Pharmaceutical grade applications
Nerve repair injection: 5-10mg/mL concentration, targeted delivery to the brain (liposome encapsulation technology).
Cancer adjuvant therapy: combined with chemotherapy drugs to reduce nephrotoxicity (clinical results show a 60% reduction in incidence).
Functional foods and skin care products
Energy drinks: add 0.5-1g per liter, pH tolerance range 3-9, suitable for sports recovery formula.
Anti-aging essence: add 1-3% concentration to inhibit collagen degradation (clinical results show that skin elasticity increases by 18%).
Usage Guidelines and Taboos
Recommended regimen:
Daily health care: 100-200 mg/day, taken after meals (fat-soluble formulas are recommended to be taken with oils).
Disease assistance: 200-1000 mg/day, under doctor's guidance (such as patients with neurodegenerative diseases).
⛔ Contraindications:
Pregnant women, lactating women and those with coagulation disorders should use with caution.
Avoid using with anticoagulants (such as warfarin) and take 2 hours apart.
Quality assurance system
• Activity test: Autophagy induction test report (RAW264.7 cell model) is provided for each batch.
• Stability data: 40℃ accelerated for 6 months, purity decreased by <1%.
• Customized service:
High temperature resistant embedding (50% activity of baked food is retained)
Enteric coating technology (survival rate in gastric acid environment>90%)
Specification Of Analysis
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Item |
Specification |
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Assay |
NLT 98% |
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Organoleptic |
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Appearance |
Powder |
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Color |
White |
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Odor |
Characteristic |
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Taste |
Characteristic |
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Physical Characteristics |
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Clarity |
Clear |
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Particle Size |
100% through 80 mesh |
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Loss on Drying |
<0.5% |
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Residue on Ignition |
<0.1% |
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Heavy metals |
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Total Heavy Metals |
<10ppm |
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As |
<2.0ppm |
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Pb |
<2.0ppm |
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Cd |
<0.5ppm |
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Hg |
<0.5ppm |
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Microbiological Tests |
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Total Plate Count |
<1,000cfu/g |
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Total Yeast & Mold |
<100cfu/g |
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E. Coli |
Negative |
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Salmonella |
Negative |
Delivery & Shipping
We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping, We can ship to all over the world, even to some remote areas, such as remote areas of Russia, countries near the north and south poles.
