+86 13759939507
Sodium Hyaluronate | Medical Grade Moisturizing & Anti-Aging
-
Certificates
+ISO9001; HACCP -
Product Specification
+95% Sodium Hyaluronate -
Factory Environment
+CGMP Factory
-
Product Advantages
+Batch Ready Stock; Raw material guarantee -
Product Evaluation
+Testing Report; Meet EU Grade -
Product Deliveries
+DHL, Fedex, UPS, EMS, as request
Sodium Hyaluronate | Cross-domain Bioactive Solutions
Product traceability and process advantages
Production standards:
Fermentation technology: Genetically engineered Streptococcus zooepidemicus CAS 9082-95-5, in line with EP/USP pharmaceutical standards
Molecular weight control:
Low molecular weight (50-100kDa): transdermal absorption rate > 80% (nanomicrosphere technology)
Medium molecular weight (1-1.5MDa): long-lasting moisturizing (skin retention time > 48h)
High molecular weight (2.4MDa): orthopedic joint lubrication (viscoelasticity comparable to natural synovial fluid)
Purification process:
Ultrafiltration desalting (endotoxin <0.05EU/mg)
Activated carbon adsorption (protein residue <0.1%)
Scientific definition and mechanism of action
Sodium hyaluronate (HA) is a natural polysaccharide composed of N-acetylglucosamine and glucuronic acid, which is mediated by CD44 receptors to achieve:
Water-locking matrix: 1g HA can bind 6L water molecules (hydrogen bond + charge adsorption)
Signal regulation: Activate the ERK pathway to promote collagen synthesis (type III collagen increased by 45%)
Mechanical protection: Dynamic viscoelasticity buffers joint pressure (oscillation shear test loss angle tanδ=0.25)
Clinically proven efficacy
Medical Aesthetics and Skin Health
▶ Dermal filler: Cross-linked HA (20mg/mL) improved the depth of nasolabial fold by 3.2 levels (GAIS score, n=150)
▶ Postoperative repair: 0.2% topical HA gel accelerated the disappearance time of erythema after laser surgery by 42% (J Cosmet Dermatol 2023)
Bone and joint health
▶ Knee joint injection (60 mg/time): WOMAC pain index decreased by 58% (6-month follow-up of OA patients)
▶ Oral administration of 80 mg/day: synovial fluid viscosity increased by 35% (verified by ultrasound elastography)
Ophthalmic and surgical applications
▶ Viscoelastic for ophthalmic surgery: 1.4% concentration maintains anterior chamber depth > 3mm (PHACO surgery success rate 99%)
▶ Prevention of postoperative adhesion: 0.1% HA gel reduces the incidence of abdominal adhesion by 78% (rat model)
Food innovation
▶ Oral beauty: 120mg/day HA increases skin moisture by 32% (tested by stratum corneum moisture meter)
▶ Sports nutrition: synergistic with type II collagen, VAS score of joint discomfort is reduced by 45%Hawthorn fruit powder is made from hawthorn fruit as the main raw material. Fresh hawthorn fruit is rich in dietary fiber. It is washed, pitted, and juiced to become hawthorn juice. Usually no preservatives or artificial colors are added to retain the original sweet and sour flavor of hawthorn. It is then filtered and the filtered hawthorn juice is concentrated into hawthorn fruit concentrated juice. The concentrated juice is spray-dried into powder, which is hawthorn fruit powder.Technical parameters
| Indicators | Specifications |
| Molecular weight range | 50kDa-2.4MDa (customizable) |
| Purity | ≥98% (HPLC, no protein residue) |
| Dynamic viscosity (1%) | 200-2,000 Pa·s (25℃) |
| Recommended dosage | Skin care products: 0.1-2% Medical cosmetic fillers: 15-25mg/mL |
| Sterilization method | γ-ray irradiation (25kGy, SAL 10⁻⁶) |
Application Scenarios and Formulation Guide
Medical beauty products
Cross-linked filler: Using BDDE cross-linking technology (residue <2ppm), the durability is up to 1 2-18 months
Water light injection formula: 1.5% HA + 5% glutathione (whitening + moisturizing dual effect)
Functional skin care products
Per-use essence: 1% ultra-low molecular weight HA (50kDa) + Ecdoin, directly reaching the dermis for repair
Medical dressing: 0.8% HA + recombinant human collagen, Class II medical device registration
sports nutrition
Joint health capsules: 80mg HA/capsule + type II collagen (from chicken sternum), UC-II® synergistic formula
Sports recovery drink: 0.05% HA microencapsulation, improves the viscoelasticity of synovial fluid
Food grade innovation
Oral beauty gummies: 120mg HA/capsule + astaxanthin, Japanese FOSHU certified formula
Middle-aged and elderly milk powder: 500mg HA added per 100g to improve joint flexibility
Usage Guidelines and Taboos
Recommended solution:
Skin care products: 0.1-2% addition (pH 5.5-7.0 stable)
Medical beauty injection: 0.1-0.3mL per point (doctor required)
Oral health care: 60-120mg/day, take after meals
Quality assurance system
• Biosafety:
Cytotoxicity test (MTT method, survival rate > 90%)
Sensitization test (HRIPT, no irritation reaction)
• Stability data:
After 3 years of storage at 4°C, molecular weight degradation <5%; high temperature accelerated test (40°C/6 months), viscosity retention >85%
FAQ Section (Long-tail keyword layout)
Q: What is the difference between this product and HA extracted from chicken comb?
A: This product uses microbial fermentation, has no risk of avian influenza virus, and has more precise molecular weight control (RSD < 3%).
Q: How to solve the problem of HA degradation?
A: We provide liposome encapsulation technology (lyophilized powder form), and the activity retention is >95% after 18 months of storage at room temperature.
Q: Does it support terminal product registration?
A: We can provide a DMF registration number (US DMF# 35421) to speed up the medical device declaration process.
Specification Of Analysis
|
Item |
Specification |
| Maker Compounds |
Glucuronic Acid NLT 44.5% |
|
Sodium Hyaluronate NLT 87% |
|
|
Organoleptic |
|
| Appearance | Fine Powder |
| Color | White |
| Odor | Characteristic |
| Taste | Characteristic |
| Average Relative Molecular Weight (Da) | Measured Value |
| PH （1mg/ml，25℃） | 6.0-8.0 |
|
Physical Characteristics |
|
| Particle Size (80 mesh) | 100.0%pass 80mesh |
| Moisture | <1.0% |
| Acid Insoluble Ash | <0.2% |
| Transmittance（1mg/ml） | T600nm≥99.0 % |
|
Heavy metals |
|
| Total Heavy Metals | <10ppm |
| As | <2.0ppm |
| Pb | <2.0ppm |
| Cd | <0.5ppm |
| Hg | <0.5ppm |
|
Microbiological Tests |
|
| Total Plate Count | <1,000cfu/g |
| Total Yeast & Mold | <100cfu/g |
| E. Coli | Negative |
| Salmonella | Negative |
Delivery & Shipping
We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping, We can ship to all over the world, even to some remote areas, such as remote areas of Russia, countries near the north and south poles.
