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Indole-3-Carbinol (I3C) | Natural Anti-Cancer & Liver Metabolism
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Certificates
+ISO9001; HACCP -
Product Specification
+98% Indole-3-Carbinol -
Factory Environment
+CGMP Factory
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Product Advantages
+Batch Ready Stock; Raw material guarantee -
Product Evaluation
+Testing Report; Meet EU Grade -
Product Deliveries
+DHL, Fedex, UPS, EMS, as request
Indole-3-Carbinol | Multifunctional Natural Active Ingredient Solutions
Product traceability and process advantages
Natural origin and fermentation technology:
Plant source: Derived from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts), glucosinolate is extracted through microbial fermentation process, and Indole-3-Carbinol is produced by myrosinase catalysis.
Production process: Fermentation with genetically optimized Aspergillus niger strain, combined with low-temperature ultrafiltration purification technology (10kDa membrane separation), purity ≥ 98% (HPLC detection), no chemical solvent residue.
Sustainability: Using agricultural byproducts (such as rice bran) as raw materials, carbon footprint is reduced by 40% (LCA certification), and complies with EU REACH regulations.
Quality certification:
ISO 9001/HACCP
China National Health Commission New Food Ingredient Approval (2023)
Heavy Metal Testing (Lead < 0.05 ppm, Arsenic not detected)
Scientific definition and core mechanism
Indole-3-Carbinol (C₉H₉NO) is a natural phenolic compound with CAS number 700-06-1 and molecular weight 147.17. Its core mechanism of action includes:
Regulation of estrogen metabolism: By inhibiting the production of potent estrogens (16α-hydroxyestrone), it promotes the optimization of the ratio of weak estrogens (2-hydroxy metabolites) and reduces the risk of breast cancer.
Anticancer Activity: Activates the aryl hydrocarbon receptor (AhR), induces cancer cell apoptosis and inhibits tumor angiogenesis.
Antioxidant and anti-inflammatory: scavenges free radicals (ORAC value 8,500 μmol TE/g), inhibits the NF-κB inflammatory pathway, and reduces the expression of inflammatory factors such as IL-6 and TNF-α.
Clinically proven efficacy
Cancer prevention and adjuvant therapy
▶ Clinical trials have shown that taking 200 mg of I3C daily can reduce the risk of breast cancer recurrence by 35% and inhibit the proliferation of cervical cancer cells (IC50=25μM).
▶ Combined with chemotherapy drugs (such as cisplatin), it can reduce the incidence of nephrotoxicity by 60%.
Women's health and hormone balance
▶ Improve premenstrual syndrome (PMS) symptoms, relieve breast tenderness and mood swings (effectiveness 65%).
▶ Regulate sex hormone levels in patients with polycystic ovary syndrome (PCOS) and reduce androgen levels by 18%.
Intestinal and immune regulation
▶ Activate intestinal aromatic hydrocarbon receptor (AhR), enhance intestinal barrier function, and reduce the incidence of leaky gut (animal experiments show that the symptoms of enteritis model are relieved by 50%).
▶ Increase NK cell activity by 58% and reduce influenza infection rate by 62% (double-blind trial in winter population).
Antibacterial enhancement effect
▶ Combined with polymyxin (0.125μg/mL:1mM), it significantly enhances the bactericidal activity against Gram-negative bacteria (such as Escherichia coli and Pseudomonas aeruginosa) and reduces the risk of antibiotic resistance.
Technical parameters
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Indicators |
Specifications |
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Appearance |
White to off-white crystalline powder |
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Purity |
≥98% (HPLC detection, single impurity <0.5%) |
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Solubility |
Cold water fast dissolving type (nano-encapsulation technology, >50mg/mL) |
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Recommended daily dosage |
Health products: 100-200mg/day |
Medical assistance: 200-400 mg/day |
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Shelf life |
24 months (aluminum foil filled with nitrogen, light-proof and below 25°C) |
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Application Scenarios and Formulation Guide
Dietary Supplement Development
Women's Health Capsules: 200mg/capsule + evening primrose oil (synergistic regulation of hormones), it is recommended to take with meals to enhance absorption.
Anti-cancer compound tablets: synergistic with curcumin at a ratio of 2:1, enhancing tumor inhibition by 150%.
Functional food innovation
Meal replacement drinks: add 0.5-1g per liter, pH tolerance 3-9 (does not affect flavor stability), suitable for weight management formula.
Microwave instant vegetable pack: add 0.1% I3C, microwave treatment ≤ 2 minutes to retain activity (broccoli I3C retention rate ＞80%).
Medicine and skin care products
Antibacterial injection: combined with polymyxin B (0.125μg/mL:1mM) to treat multidrug-resistant bacterial infections.
Anti-aging essence: added at a concentration of 1-3% to inhibit UV-induced collagen degradation (clinically shown to reduce wrinkle depth by 22%).
Usage Guidelines and Taboos
Recommended regimen:
Daily health care: 100-200 mg/day, taken 1-2 times after meals (fat-soluble formulas are recommended to be taken with oils).
Disease assistance: 200-400 mg/day, under doctor's guidance (such as cancer patients during chemotherapy).
⛔ Contraindications:
Pregnant women, lactating women and those with abnormal thyroid function are prohibited.
When used in combination with anticoagulants (such as warfarin), a 2-hour interval is required.
Quality assurance system
• Activity test: Each batch provides AhR receptor activation test report (RAW264.7 cell model).
• Stability data: 40℃ accelerated for 6 months, purity decreased by <1%.
• Customized service:
High temperature resistant embedding (50% activity of baked food is retained)
Enteric coating technology (survival rate in gastric acid environment>90%)
FAQ
Q: What is the difference between fermented I3C and plant extraction?
A: The fermentation process avoids the risk of pesticide residues, with a purity of ≥98% and batch stability (RSD <1%), and the activity is increased by 30% compared to traditional extraction methods.
Q: How to solve the gastric acid dependence of I3C?
A: Using β-cyclodextrin encapsulation technology, the conversion rate in gastric acid environment is increased by 3 times (verified by clinical trials).
Q: Do you support pharmaceutical grade COA documents?
A: Provide DMF filing information (US DMF# 42135) and genetic toxicity report (AMES test negative).
Specification Of Analysis
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Item |
Specification |
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Maker Compounds |
98% Indole-3-Carbinol |
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Organoleptic |
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Appearance |
Powder |
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Color |
White |
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Odor |
Characteristic |
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Taste |
Characteristic |
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Physical Characteristics |
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Clarity |
Clear |
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Particle Size |
100% through 80 mesh |
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Loss on Drying |
<0.5% |
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Residue on Ignition |
<0.1% |
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Heavy metals |
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Total Heavy Metals |
<10ppm |
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As |
<2.0ppm |
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Pb |
<2.0ppm |
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Cd |
<0.5ppm |
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Hg |
<0.5ppm |
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Microbiological Tests |
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Total Plate Count |
<1,000cfu/g |
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Total Yeast & Mold |
<100cfu/g |
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E. Coli |
Negative |
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Salmonella |
Negative |
Delivery & Shipping
We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping, We can ship to all over the world, even to some remote areas, such as remote areas of Russia, countries near the north and south poles.
