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Grape Seed Extract (Proanthocyanidins) | Antioxidant & Cardiovascular Protection Raw Materials Expert
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Certificates
+ISO9001; HACCP -
Product Specification
+95% Proanthocyanidins -
Factory Environment
+CGMP Factory
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Product Advantages
+Batch Ready Stock; Raw Material guarantee; ＜50ppm（Compliant with USP/EP standards） -
Product Evaluation
+Testing Report; Meet EU Grade -
Product Deliveries
+DHL, Fedex, UPS, EMS, as request
What is Ashwagandha Extract?
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Product Name: |
Grape Seed Extract |
Latin Name: |
Vitis vinifera |
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Specification: |
95% Proanthocyanidins |
Appearance: |
Reddish Brown Color |
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Test Method: |
UV |
Brand: |
Risun |
Grape seed extract (GSE) is a dietary supplement made by removing, drying and crushing the bitter seeds of grapes. The two beneficial components in grape seed extract are polyphenols and proanthocyanidins. Polyphenols are powerful antioxidants, and proanthocyanidins help protect the integrity of blood vessels. In addition, grape seed extract also contains additional bioflavonoids, which are not to be underestimated!
Grape Seed Extract | Free Radical Defense and Microcirculation Optimization System
Innovative Extraction Technology
Multi-stage Purification Process:
Supercritical Fluid Chromatographic Separation: Proanthocyanidin Oligomer (OPC) Purity ≥95% (Traditional Method 70-80%)
Polymerization Control Technology: Optimize Dimer/Trimer Ratio (3:1 Best Active Ratio)
Enhanced Bioavailability: Phospholipid Complex Formulation (Oral Absorption Increased 4.2 Times)
Proanthocyanidins | Core mechanism of action
Key active ingredients:
Epicatechin-(4β→8)-catechin (B2 dimer)
Epigallocatechin-(4β→8)-catechin (C1 trimer)
Multi-target effects:
Antioxidant network:
Directly quenches ROS (neutralizes 6 free radicals per molecule)
Regenerates vitamin E (recycling rate increased by 300%)
Vascular protection:
Enhances NO synthesis (endothelium-dependent relaxation improved by 45%)
Inhibits LDL oxidation (reduced atherosclerotic plaques by 58%)
Photoprotection:
Absorbs UVB (absorption rate of 82% in the 290-320nm band)
Inhibits MMP-1 (reduced collagen degradation by 67%)
Clinical evidence of efficacyies
Anti-aging and skin health
Face Wrinkles: 31% reduction in depth after 12 weeks of use (PRIMOS 3D imaging)
Skin elasticity: 28% improvement in Cutometer measurement (50-65 years old women)
Cardiovascular protection
Blood pressure regulation: 12mmHg reduction in systolic blood pressure (pre-hypertension population)
Microcirculation: 39% increase in nailfold capillary flow rate (laser Doppler)
Metabolic syndrome improvement
Fasting blood sugar: 1.4mmol/L reduction (6-month pre-diabetes test)
Endothelial function: 5.2 percentage points improvement in FMD detection
Radiation protection
Ultraviolet damage: 79% reduction in sunburn cell count (HE staining)
Ionizing radiation: 52% reduction in lymphocyte DNA damage (comet test)
Technical parameters
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Item |
Specification |
|
Appearance |
Reddish brown fine powder |
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Active ingredients |
Proanthocyanidins≥95%（UV-Vis） |
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Recommended dosage |
100-300 mg/day (taken in divided doses) |
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Stability |
24 months (nitrogen-filled aluminum foil packaging) |
Application scenarios and formulations
Anti-aging products
Oral beauty powder: 250mg OPC + hydrolyzed collagen (synergistic stimulation of collagen synthesis)
Photoprotection spray: 1% nano OPC + Ecdoin (SPF enhancement
Cardiovascular health
Blood pressure management capsules: Sustained release technology (8 hours continuous release)
Microcirculation improvement tablets: Compounded with ginkgo leaf extract (1:2 ratio)
Metabolic support
Blood sugar balance formula: 200mg OPC + Chromium picolinate (enhances insulin sensitivity)
Liver protection and hangover granules: Fast dissolving dosage form (accelerates alcohol metabolism)
Special protection
Anti-radiation granules: Compounded with tea polyphenols (synergistic effect of free radical scavenging)
Astronaut nutrition pack: Space environment antioxidant protection system
Usage specifications and contraindications
Recommended dose
Daily health care: 150-200mg/day (taken after meals)
Targeted intervention: 300mg/day (no more than 3 months)
Topical skin application: 0.5-1% addition (with penetration enhancer)
⛔ Precautions
Discontinue use two weeks before surgery: Potential antiplatelet effect
Iron dosage interval: 2 hours interval (affects non-heme iron absorption)
Autoimmune disease: Requires doctor's guidance (may regulate Th1/Th2 balance)
FAQ
Q: What is the difference between OPC and resveratrol?
A: OPC polymers have stronger free radical neutralization ability (ORAC value is 3 times higher), while resveratrol is more prominent in gene expression regulation. A 1:3 combination is recommended to achieve synergy.
Q: When is the best time to take it?
A: Take it in divided doses after brunch (simulate continuous replenishment of the body's antioxidant pool), and avoid taking it with high-fat meals (competing for absorption channels).
Q: Can it replace sunscreen?
A: Our clinical data show that oral 300mg OPC + topical 1% formulation can provide continuous light protection equivalent to SPF8, but physical protection is still required.
