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Fermented PQQ（Pyrroloquinoline Quinone）|Cellular Energy And Anti-Aging
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Certificates
+ISO9001; HACCP -
Product Specification
+98% PQQ -
Factory Environment
+CGMP Factory
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Product Advantages
+Batch Ready Stock; Raw material guarantee -
Product Evaluation
+Testing Report; Meet EU Grade -
Product Deliveries
+DHL, Fedex, UPS, EMS, as request
What is PQQ?
PQQ, which stands for pyrroloquinoline quinone, is a red compound that is also a vitamin and nutrient. It plays an important role in accelerating the body's metabolic processes, promoting cell growth and division. PQQ is an essential nutrient in the process of animal reproduction, growth and development, and is considered to be a bioactive substance with the strongest ability to catalyze redox reactions. Due to its unique physicochemical properties, PQQ has shown a wide range of effects in scavenging free radicals, antioxidant, inhibiting inflammatory responses, anti-apoptosis, regulating mitochondrial function and energy metabolism, nutrition and promoting growth. In addition, PQQ has good application prospects and broad market prospects in the prevention and treatment of multi-system and multi-organ related diseases such as heart disease, liver disease, nervous system disease, osteoporosis and cancer.
Product traceability and process advantages
Fermentation technology:
Strain patent: Using genetically engineered strain Methylovorus glucosotrophus (approved by the National Health Commission of China), PQQ is synthesized through microbial fermentation, with a purity 30% higher than that of chemical synthesis, and no risk of solvent residue.
Process highlights:
Continuous flow fermentation: 48 hours of efficient conversion, yield of more than 85%, 40% cost reduction.
Membrane separation and purification: 10kDa ultrafiltration technology removes impurities, and the final product purity is ≥98% (HPLC test).
Sustainability: Zero animal-derived ingredients, 50% less carbon footprint (LCA certified), compliant with EU REACH regulations.
Certification system:
ISO 9001/HACCP
Heavy metal detection (lead < 0.05 ppm, arsenic not detected)
Scientific definition and mechanism of action
PQQ (C₁₄H₆N₂O₈) is a quinone redox coenzyme that achieves the following through multi-target regulation:
Mitochondrial activation: Stimulates mitochondrial biosynthesis (increases new mitochondria by 163%) and improves ATP generation efficiency.
Antioxidant network: Activate the Nrf2-Keap1 pathway, catalyzes 20,000 redox cycles (vitamin C only 4 times), and has a free radical scavenging capacity 5,000 times greater than VC.
Neuroprotection: Inhibit over-activation of NMDA receptors, reduce neuronal oxidative damage, and promote 25% increase in cerebral blood flow (verified by near-infrared imaging).
Clinically verified efficacies
Enhancement of cognitive function
▶20mg/day for 12 weeks, 7 cognitive indicators of healthy adults improved (including memory, reaction speed, executive function), and cerebral blood flow increased by 18% in people aged 40-80 years.
▶ Clinical trials show that young people aged 20-40 years old have a 22% increase in processing speed after 8 weeks.
Bone health protection
▶ Prevention of senile osteoporosis: 18-month-old mice supplemented with PQQ for 6 months, osteoblast activity increased by 30%, and osteoclast inhibition rate by 45% (Aging Cell 2023).
▶ Experiments on human intervertebral disc cells confirmed the reduction of oxidative damage markers (ROS reduced by 60%).
Metabolism and immune regulation
▶ Reduce the levels of inflammatory factors IL-6 and TNF-α by 40%, and improve chronic inflammation.
▶ Enhance NK cell activity by 58% and reduce the frequency of upper respiratory tract infections by 62% (winter population test).
Cardiovascular and liver protection
▶ Reduce myocardial ischemia-reperfusion injury and protect mitochondrial membrane potential (better than metoprolol).
▶ Reduce serum transaminase (ALT/AST) by 35% and relieve alcoholic liver damage
Technical parameters
| Item | Specification |
| Appearance | Yellow to brownish-yellow powder |
| Purity | ≥98% (HPLC, single impurity <0.5%) |
| Solubility | Cold water instant type (>50mg/mL) |
| Recommended dosage | Dietary supplement：20-40mg/day; Functional food：0.1-0.3% addition |
| Shelf life | 24 months (aluminum foil nitrogen packaging, below 25℃) |
Application scenarios and formulation guidelines
Dietary supplement development
Brain power capsule: 20mg PQQ + 100mg acetyl-L-carnitine + 30mg coenzyme Q10 (synergistically enhance mitochondrial function).
Anti-fatigue tablets: Compounded with green tea extract (EGCG:PQQ=2:1), prolonging exhaustion time by 28%.
Functional food innovation
Energy drinks: Add 0.5-1g per liter, pH tolerance range 3-9 (does not affect flavor stability).
Elderly nutrition powder: 0.2% addition + calcium, prevent osteoporosis (clinically recommended dose).
Medical grade application
Orthopedic injection: 5mg/mL concentration, inhibits intervertebral disc degeneration (mouse model verification).
Liver protection preparation: Nanoliposome encapsulation technology, targeted delivery to liver cells.
Usage specifications and contraindications
Recommended solutions:
Daily health care: 20 mg/day, taken after meals (bioavailability increased by 30%)
Disease assistance: 40 mg/day, taken in 2 doses (doctor's guidance required)
Quality assurance system
• Activity detection: Each batch provides Nrf2 pathway activation experiment report (RAW264.7 cell model).
• Stability data: 40℃ accelerated for 6 months, purity decreased by <1%, and viable bacteria survival rate>90%.
• Customized services:
Microencapsulation technology (masking bitterness, suitable for beverages)
High temperature resistant embedding (150℃ baked food activity retained 50%)
FAQ Section
Q: What is the difference between fermented PQQ and chemical synthesis?
A: The fermentation process has no solvent residue, purity ≥98% and contains natural isomers, and the biological activity is 30% higher than that of chemical synthesis.
Q: How to solve the problem of poor water solubility of PQQ?
A: Using β-cyclodextrin embedding technology, the solubility is increased to 50mg/mL (cold water instant dissolution).
Q: Do you support pharmaceutical grade COA documents?
A: Provide a full set of DMF filing materials (US DMF# 42135) and genetic toxicity report (AMES test negative).
Specification Of Analysis
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Item |
Specification |
| Maker Compounds | NLT 98% (Dry Basis) |
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Organoleptic |
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| Appearance | Fine Powder |
| Color | Reddish Orange to Reddish Brown |
| Odor | Characteristic |
| Taste | Characteristic |
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Physical Characteristics |
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| Clarity | Clear |
| Particle Size | 100% through 20 mesh |
| Loss on Drying | <0.5% |
| Residue on Ignition | <0.1% |
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Heavy metals |
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| Total Heavy Metals | <10ppm |
| As | <1.0ppm |
| Pb | <0.5ppm |
| Cd | <1.0ppm |
| Hg | <0.1ppm |
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Microbiological Tests |
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| Total Plate Count | <1,000cfu/g |
| Total Yeast & Mold | <100cfu/g |
| E. Coli | Negative |
| Salmonella | Negative |
Delivery & Shipping
We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping, We can ship to all over the world, even to some remote areas, such as remote areas of Russia, countries near the north and south poles.
