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Fermented Melatonin | Natural Sleep Aid & Biological Clock Regulation
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Certificates
+ISO9001; HACCP -
Product Specification
+99% Melatonin -
Factory Environment
+CGMP Factory
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Product Advantages
+Batch Ready Stock; Raw material guarantee -
Product Evaluation
+Testing Report; Meet EU Grade -
Product Deliveries
+DHL, Fedex, UPS, EMS, as request
What is Melationin?
Melatonin (melatonin) is also known as melatonin, melatonin, melatinin, pineal renaline, and is also known as the "sleep vitamin". It is an amine hormone produced by the pineal gland of the brain, and its secretion has a circadian rhythm, the secretion is inhibited during the day, the secretion is active at night, and the lights at night also prevent the production of melatonin. As we age, the body's own melatonin secretion tends to decline. Melatonin supplements are commonly used for sleep disorders, such as jet lag, body clock, insomnia, and sleep problems in night shift workers, and it has also been studied for Alzheimer's symptoms.
Product traceability and process advantages
Fermentation technology:
Strain patent: The fermentation production is carried out by using genetically engineered optimized Saccharomyces cerevisiae, which has a purity 30% higher than that of chemical synthesis and has no risk of solvent residue.
Process highlights:
Low-temperature purification: 10kDa ultrafiltration membrane separation technology, removes impurity proteins, purity ≥99% (HPLC detection).
Stability optimization: freeze-drying technology combined with nano-encapsulation, activity retention >95% after 24 months of storage at room temperature.
Sustainability: zero animal-derived ingredients, compliant with EU REACH regulations, and 40% reduction in carbon footprint (LCA certification).
Quality certification:
ISO 9001/HACCP
China National Health Commission's new food raw material approval (2023)
Heavy metal detection (lead < 0.05ppm, arsenic not detected).
Scientific definition and core mechanism
Hawthorn fruit powder is made from hawthorn fruit as the main raw material. Fresh hawthorn fruit is rich in dietary fiber. It is washed, pitted, and juiced to become hawthorn juice. Usually no preservatives or artificial colors are added to retain the original sweet and sour flavor of hawthorn. It is then filtered and the filtered hawthorn juice is concentrated into hawthorn fruit concentrated juice. The concentrated juice is spray-dried into powder, which is hawthorn fruit powder.
What is Hawthorn Fruit Powder?
Melatonin (C₁₃H₁₆N₂O₂) is an indole heterocyclic hormone secreted by the pineal gland that regulates physiological functions through the following mechanisms:
Circadian rhythm regulation: inhibits the interference of blue light on the pineal gland and promotes the peak of melatonin secretion at night (23:00 to 3:00 in the morning).
Antioxidant network: Its free radical scavenging efficiency is 5 times that of vitamin C, delaying photoaging (ORAC value reaches 8,500 μmol TE/g).
Neuroprotection: Reduce oxidative stress damage through the blood-brain barrier and improve memory in patients with mild cognitive impairment (clinical trials show an 18% increase in cognitive scores).
What is Hawthorn Fruit Powder?
Hawthorn fruit powder is made from hawthorn fruit as the main raw material. Fresh hawthorn fruit is rich in dietary fiber. It is washed, pitted, and juiced to become hawthorn juice. Usually no preservatives or artificial colors are added to retain the original sweet and sour flavor of hawthorn. It is then filtered and the filtered hawthorn juice is concentrated into hawthorn fruit concentrated juice. The concentrated juice is spray-dried into powder, which is hawthorn fruit powder.
Clinically proven efficacy
1️⃣ Sleep rhythm adjustment
▶ Shorten the time to fall asleep by 40%, improve the sleep efficiency of jet lag and shift workers (double-blind trial, n=200).
▶ Elderly people (over 60 years old) took it for 3 consecutive months, and the number of awakenings at night decreased by 55%.
2️⃣ Antioxidant and skin health
▶ Inhibits tyrosinase activity, clinically shown to reduce the area of pigmentation by 22% after 8 weeks.
▶ Promotes collagen synthesis and improves the loss of skin elasticity caused by ultraviolet rays (wrinkle depth reduced by 19%).
3️⃣ Assisted medical applications
▶ Cancer chemotherapy adjuvant: Reduce the incidence of cisplatin nephrotoxicity by 60% and improve the quality of life of patients.
▶ Cardiovascular protection: Reduce systolic blood pressure of hypertensive patients by 12mmHg (100mg/d, for 12 weeks).
Technical parameters
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Indicators |
Specifications |
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Appearance |
White to off-white crystalline powder |
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Purity |
≥99% (HPLC detection, single impurity <0.5%) |
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Solubility |
Quickly dissolve in cold water (nano-encapsulation technology, >50mg/mL) |
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Recommended daily dosage |
1-3mg/day (take once 30 minutes before bedtime) |
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Shelf life |
24 months (aluminum foil nitrogen-filled packaging, below 25°C) |
Application Scenarios and Formulation Guide
Dietary Supplement Development
Sleeping gummies: 1mg/tablet + GABA (γ-aminobutyric acid), pH tolerance 3-9, suitable for young consumers.
Sustained-release tablets: 2mg/tablet, prolong the blood drug concentration maintenance time, suitable for people who wake up easily at night.
Functional food innovation
Sleep-aiding drinks: Add 0.5-1g per liter and compound with Chinese date seed extract (synergistic sedative effect increased by 30%).
Elderly milk powder: 0.1% added amount + calcium supplement to improve osteoporosis and regulate sleep.
Pharmaceutical grade applications
Chemotherapy adjuvant preparation: compounded with glutathione (ratio 1:3) to reduce drug-induced liver injury.
Targeted delivery system: liposome encapsulation technology (particle size <100nm) to improve brain bioavailability.
Usage Guidelines and Taboos
✅ Recommended regimen:
Daily sleep aid for adults: 1-3mg/day, continuous use ≤13 weeks (needs periodic discontinuation).
Medical assistance: 5-10mg/day (needs doctor's guidance, liver function monitoring).
⛔ Contraindications:
Pregnant women, lactating women, and adolescents (<20 years old) are prohibited from using (interfering with endocrine development).
Use with caution in patients with autoimmune diseases (such as rheumatoid arthritis) and epilepsy (may aggravate symptoms).
Interactions exist with anticoagulants (warfarin) and immunosuppressants.
Quality assurance system
• Activity test: RAW264.7 cell model antioxidant test report is provided for each batch.
• Stability data: 40℃ accelerated for 6 months, purity decreased by <1%.
• Customized service:
Flavor optimization (natural citrus essential oil masks bitterness)
High temperature resistant embedding (50% activity retention in baked goods)
FAQ
Q: What is the difference between fermented melatonin and chemically synthesized products?
A: The fermentation process has no solvent residue, retains the natural isomers, and increases biological activity by 30%
Q: How to solve the problem of low oral bioavailability?
A: Using β-cyclodextrin encapsulation technology, the absorption rate is increased from 15% to 60%.
Specification Of Analysis
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Item |
Specification |
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Maker Compounds |
98% Coenzyme Q10 |
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Organoleptic |
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Appearance |
Crystal Powder |
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Color |
White |
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Odor |
Characteristic |
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Taste |
Characteristic |
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Physical Characteristics |
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Clarity |
Clear |
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Particle Size |
100% through 80 mesh |
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Loss on Drying |
<0.5% |
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Residue on Ignition |
<0.1% |
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Heavy metals |
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Total Heavy Metals |
<10ppm |
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As |
<2.0ppm |
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Pb |
<2.0ppm |
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Cd |
<0.5ppm |
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Hg |
<0.5ppm |
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Microbiological Tests |
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Total Plate Count |
<1,000cfu/g |
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Total Yeast & Mold |
<100cfu/g |
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E. Coli |
Negative |
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Salmonella |
Negative |
Delivery & Shipping
We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping, We can ship to all over the world, even to some remote areas, such as remote areas of Russia, countries near the north and south poles.
