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Wild Jujube Extract
Product name: Wild Jujube Extract
Botanical Source: Ziziphus jujuba Mill
Part Used: Seeds
Appearance: Brown fine powder.
Specifications: 0.18% Jujubosides(HPLC);2% Jujubosides(UV)
Test Method: HPLC/ UV
The Wild Jujube herb is the seed from the fruit of the subspecies Zizyphus jujuba var. spinosa (also spelled Ziziphus), which is a spiny deciduous tree native to East Asia. The seed is removed from the ripe drupe collected during late autumn and early winter and is dried in the sun. "Sour Date Seed" or "Suanzaoren" is believed in Traditional Chinese Medicine to be the best herb in the TCM repertoire for calming disturbed "shen" (spirit) with symptoms of nervous exhaustion, fatigue, irritability, and insomnia. Classified as a nutritive sedative, it calms the mind, relaxes and nourishes muscles, nourishes the blood, spleen and liver, helps to conserve energy, and is analgesic.
Scientific studies with animals have shown Wild Zizyphus seed to have anti-anxiety and hypnotic effects, causing a reduction in the speed of conditioned reflexes, a reduction in hyperactivity, and a lowering of blood pressure. Oral administration of the decoction of the herb prolonged sodium pentobarbital induced sleep in mice and significantly caused a subthreshold dose of sodium thiopental to induce anesthesia in rabbits. In human clinical studies, a significant tranquilizing effect of Zizyphus was found to measurably potentiate the concurrent administration of tranquilizing drugs.
Other effects of Wild Jujube seed augment its calming and sleep inducing effects, revealing potential for additional product applications. Because of its muscle relaxing effects, the herb is sometimes used as an anticonvulsant. Animal studies have demonstrated it effectiveness in reducing pain sensation and increasing pain tolerance, further substantiating its use as an analgesic. The herb could be useful in products for arthritis, backache, headache or any type of pain that interferes with sleep. In addition, for those with hypertension, Wild Jujube seed has been shown to produce significant, persistent and prolonged reductions in blood pressure.
The phytocompounds found in significant quantities in Wild Jujube seed are triterpene saponins, jujubosides A and B, flavone glycosides, and ferulic acid. The triterpene constituents include betulinic acid, betulin, ceanothic acid, alphitolic acid and daucosterol. The fleshy fruit surrounding the seed also contains triterpene saponins and has sedative effects, but the effects are milder than those from the seed.
Wild Jujube can be used alone or in the context of a formula. The renowned TCM Zizyphus formula, "Suanzaoren Tang", containing calming herbs like Poria cocos, has been confirmed scientifically in its ability to treat insomnia and restlessness.
While Wild Jujube Seed is the true star of Chinese herbal sedatives, product developers seeking alternatives should be careful not to overlook Chinese Skullcap (Scutellaria baicalensis), which contains among the highest levels of naturally occurring melatonin, and has constituents that bind to benzodiazepine receptors (Xanax?, Valium?, or Restoril? are tranquilizers of the benzodiazepine class). Another powerful relaxing and adaptogenic herb is "shen" tonic Reishi mushroom
1. Wild Jujube Extract can help for a good sleep and clam. It can improve the quality of the sleep and
can be used cure the depression.
2. Wild Jujube Extract also has a function of inhibitor eclampisa and low the body temperature
3. Wild Jujube Extract for the cardiovascular system,it is a good cardiotonic and also have a positive
effect for the expansion of microvascular diameter.
4.Uses and Pharmacology
CNS:Jujube is used traditionally as an anxiolytic and sedative. Animal experiments using the saponin jujuboside and flavonoids from the fruits, as well as the seed extract, showed reductions in anxiety, impaired coordination and responses, and enhanced barbiturate-induced hypnotic effects.
In a plant screening exercise, oleamide from a jujube extract given for 3 weeks attenuated scopolamine-induced amnesia in mice. A role in cognitive impairment disorders, such as that seen in Alzheimer disease, was suggested, as the jujube extract appeared to increase the activation of choline acetyltransferase.
Cancer:Studies using specific saponins, as well as ethyl acetate and water extracts of the fruit and bark, have explored the potential cytotoxicity of jujube. Apoptosis and differential cell cycle arrest are suggested to be responsible for the dose-dependent reduction in cell viability. Activity against certain human cancer cell lines has been demonstrated in vitro.
Gastrointestinal:Jujube fruit has traditionally been used as a paste, puree, or soup to enhance digestion. In animal experiments, jujube extract decreased GI transit time and increased fecal moisture content. Increased fatty acid concentration in the cecum and decreased fecal ammonia and bacterial enzyme activity in the feces were also measured.
In a small (N = 50) clinical trial, the symptoms of patients with chronic idiopathic constipation improved with daily consumption of jujube extract (average, 20 drops per day) versus placebo. Because of practical issues, GI transit times were not measured in the study. Jujube extract may offer a safe natural laxative option.
Net weight: 25Kg per Drum. Packed in two plastic-bags with paper-drum outside Or
as per customers request.
Storage: Store in a cool, dry and well-sealed container; Keep away from moisture and
Shelf life: Two years under specified environment.