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Perilla Extract

Perilla Extract

Risun Bio-Tech Inc is one of the leading perilla extract manufacturers and suppliers, welcome to buy factory supply pure natural and 100% natural perilla extract of both low price and high quality. Perilla Extract Product Name: Perilla Extract Botanical Source: Perilla frutescens L. Part Used:...

Technical Parameter

Risun Bio-Tech Inc is one of the leading perilla extract manufacturers and suppliers, welcome to buy factory supply pure natural and 100% natural perilla extract of both low price and high quality.

Perilla Extract 

Product Name: Perilla Extract

Botanical Source: Perilla frutescens L.

Part Used: Seed

Appearance: Brown fine powder.

Specification: 10:1

Test Method: TLC

Health Benefits:

Inducing sweat to dispel exopathogens, promoting the Qi flow to alleviate stagnation in the middle Jiao, and detoxifying fish and crab. 

Uses and Pharmacology

Antioxidant properties of perilla leaf and seed extracts, as well as individual chemical constituents, have been extensively studied in experimental models,  with limited therapeutic applications evaluated.

Anti-inflammatory and antiallergic effects

In vitro modeling has been used to describe anti-inflammatory properties of perilla. A marked influx of neutrophils and formation of leukotriene B4, along with changes in thromboxane B2 levels, was demonstrated in 1 experiment. In another, large increases in prostaglandin levels were seen. In a contact dermatitis model, perilla induced hypersensitivity mediated by leukotrienes, prostaglandins, histamine, inflammatory cytokines, and immunoglobulin E (IgE).  Extracts of perilla have also been shown to suppress the overproduction of tumor necrosis factor-alpha, a cytokine important in immunologic and inflammatory reactions. Several anti-inflammatory components of perilla leaf have been identified, including luteolin and tormentic acid. In vitro and in vivo immunoenhancing effects have been described for a crude polysaccharide extract isolated from the leaves of perilla. 

Animal data

Topically applied triterpene acids isolated from dried perilla leaves produced a marked reduction in induced ear inflammation in mice.  Greatest improvement was observed with the  of tormentic acid, an ursane triterpene. Inhibition of inflammation with this agent was similar to that produced by hydrocortisone and indomethacin. In another study, orally administered perilla leaf extract inhibited acute inflammation in 3 different models, including one for contact dermatitis. 

Clinical data

Improvement in the symptoms of seasonal allergic rhinoconjuctivitis was reported in a small study (N = 30) of perilla extract enriched with rosmarinic acid. Although objective symptom scores were not affected, patient evaluation of symptoms showed improvement scores of 30%, 55.6%, and 70% for patients receiving placebo, rosmarinic acid 50 mg, and rosmarinic acid 200 mg, respectively ( P = 0.05; placebo vs rosmarinic acid 200 mg). Numbers of inflammatory cells in nasal lavage fluid were significantly lower at 3 days in patients receiving rosmarinic acid. However, this effect was no longer apparent at 21 days. 

Cancer
Animal data


The inhibitory effects of topically applied tormentic acid on carcinogenesis have been investigated in mice. Similar results have been observed with topical application of a perilla leaf extract; the active principle in this study was thought to be luteolin. The effects of orally administered perilla leaf extract were less marked, and no difference in numbers of tumors was observed between controls and perilla-treated groups at 20 weeks. Reduction in the incidence of mammary and colonic tumors has been associated with perilla oil dietary supplementation in laboratory animals.  In vitro experiments with human leukemia and hematoma cell lines have demonstrated apoptotic and cell cycle-arresting properties for perilla leaf extract of greater effect than with rosmarinic acid alone. 

Clinical data

The constituent perilla alcohol has been studied in skin, prostate, and breast cancers, as well as for glioblastoma.

CNS effects
Animal data


In a model of age-related deficits in learning and memory, mice fed a diet enriched with perilla oil exhibited better learning performance and less hyperactive behavior than those fed an alpha-linolenate–deficient diet. Apigenin extracted from perilla was found to have limited antidepressant-like effects in mice.  In mice with stress-induced depression, perillaldehyde reduced the duration of immobility in the forced swimming test.  An anorexigenic effect has been demonstrated in mice fed apigenin both acutely and after 30 days, with no effect on blood glucose or total cholesterol but with decreased triglycerides.  In vitro studies suggest chemical constituents of perilla may act via the monoamine transport system to increase monoamine levels and via inhibition of beta-sectretase enzymes to reduce the production of amyloid protein. 

Clinical data

Research reveals no clinical data regarding the use of perilla in diseases of the central nervous system.

Other uses
Antimicrobial


Luteolin, extracted from perilla seed oil, showed marked antimicrobial activity against bacteria commonly associated with dental caries.  Activity of perilla oil against toxins produced by Staphylococcus aureus has been demonstrated. 

Dermatology

Perilla leaf extract has been shown to inhibit tyrosinase and melatonin synthesis in mice melanoma cells, suggesting potential applications for skin lightening. 

Dietary

Perilla oil is rich in alpha-linolenate; health benefits have been theorized with its use. Serum cholesterol and triglyceride levels decreased in rats fed perilla oil. Beneficial changes in the levels of eicosapentaenoic acid and arachidonic acid were also observed in these animals. A trend toward decreased lipid peroxidation was observed in a small study among healthy volunteers who consumed 5 g of powdered perilla leaves for 10 days. 

Glomerulonephritis

An orally administered perilla leaf decoction resulted in reductions in proteinuria and in the numbers of glomerular and proliferative cell nuclear antigen-positive cells in animals with mesangioproliferative glomerulonephritis. 

Dosage

Clinical trials are lacking to provide dosage recommendations. An extract of perilla enriched to contain 200 mg of rosmarinic acid has been used to treat the symptoms of seasonal allergy.  Healthy volunteers consumed 5 g of powdered perilla leaves for 10 days in another study. 

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

None well documented.

Adverse Reactions

Dermatitis has been reported in perilla oil workers. Patch testing suggests that 1-perillaldehyde and perilla alcohol contained in the oil are responsible for the effect.  Two cases of anaphylaxis resulting from oral consumption of 500 mg of perilla seeds have been reported. An IgE-mediated response was documented. 

Toxicology

Animals grazing on perilla have developed fatal pulmonary edema and respiratory distress.  Perilla ketone, chemically related to the toxic ipomeanols derived from moldy sweet potatoes, is a potent agent for the induction of pulmonary edema in laboratory animals.  Highest levels of perilla ketone occur in the plant during the flowering and seed stages.  It acts by increasing the permeability of endothelial cells and may not require the presence of cytochrome P450 to increase vascular permeability. 

The toxicity of perilla ketone has been examined in several animal species.  Low intraperitoneal median lethal dose values were observed for mice and hamsters (5 and 13.7 mg/kg, respectively), with far higher lethal doses being required for dogs and pigs (106 and 158 mg/kg, respectively). Perilla ketone-related pathology in dogs and pigs was primarily hepatic, with only minor pulmonary effects, while mice and hamsters displayed only pulmonary lesions. Enzyme bioactivation of perilla ketone may be required for toxicosis, with species unable to produce the perilla metabolite having reduced susceptibility to its poisoning. The volatile perilla oil contains the aldehyde antioxide that has been used in the tobacco industry as a sweetener; however, this compound may be toxic.

The COA of Perilla Extract:

ItemSpecificationResultMethod
Make CompoundsNTL 10:1 perilla
5.50%TLC
Organoleptic


AppearanceFine powderConformsNLS-QCS-1008
ColorBrownConformsGB/T5492-2008
OdorCharacteristicConformsGB/T5492-2008
TasteCharacteristicConformsGB/T5492-2008
Parted UsedSeedConforms/
Extract SolventWater & EthanolConforms/
Drying MethodSpary dryingConforms/

Physical Characteristic


Particle size (80 mesh)100.0% pass 80mshConformsGB/T5507-2008
Moisture<5.0%3.0%GB/T14769-1993
Ash content<5.0%2.60%AOAC 942.05,18th 
Heavy metals


Total heavy metals<10.0ppmConformsUSP<231>,method II
As<2.0ppmConformsAOAC986.15,18th
Pb<2.0ppmConformsAOAC986.15,18th
Cd<0.5ppmConformsAOAC986.15,18th
Hg<0.5ppmConformsAOAC971.21,18th

Pesticide residue


666<0.2ppmConformsGB/T5009.19-1996
DDT<0.2ppmConformsGB/T5009.19-1996
Microbiological Test


Total plate count<1000fu/g90fu/gAOAC990.12,18th
Total yeast or mold<100fu/g15fu/gFDA(BAM)Chapter18,8th Ed.
E.ColiNegativeNegativeAOAC997.11,18th
SalmonellaNegativeNegativeFDA(BAM)Chapter5,8th Ed.


Packing Detail:

Net weight: 25Kg per Drum. Packed in two plastic-bags with paper-drum outside Or as per customers request.

Storage: Store in a cool, dry and well-sealed container; Keep away from moisture and strong light/heat.

Shelf life: Two years under specified environment.


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