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Soybean Extract As An Anti-aging Ingredient
Risun Bio-Tech Inc | Updated: Jul 26, 2016

Soybean Extract As an Anti-aging Ingredient 

    Soy extracts are well known as medicinal and nutritional ingredients, and exhibit benefits towards

human skin including depigmenting or anti-ageing effects. Despite the wrinkle decreasing effects of retinoids on skin as an anti-ageing ingredient,

retinoid application can causes photo-sensitive responses such as skin irritation. Thus, their daytime usage is not recommended. The aim of this study is the investigation into the activities 

of soybean extract as an anti-ageing ingredient and their comparison to retinoids in this respect. 

    Soybean extract decreased the relative ratio of MMP-1/TIMP-1 mRNA to the same degree as retinoic

acid in normal human fibroblasts. It also affected mRNA levels of HAS2 and CRABP2 in normal human 

keratinocytes. Furthermore, we investigated its effect on mRNA expression of histidase, an enzyme 

that converts histidine into urocanic acid, the main UV light absorption factor of the stratum 

corneum. Unlike the complete inhibition of histidase exhibited by the mRNA expression of retinoic 

acid, the effect of soybean extract on histidase gene expression was weaker in normal human

keratinocytes. Also, soybean extract pretreatment inhibited UVB-induced cyclobutane pyrimidine 

dimer formation dose-dependently in normal human keratinocytes. In this study, we found that 

soybean extract modulated retinoic acid-related genes and showed photo-protective effects. Our 

findings suggest that soybean extract could be an anti-ageing ingredient that can be safely used 

under the sunlight.