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Escin Helps To Promote Circulation
Risun Bio-Tech Inc | Updated: Dec 23, 2016

Escin Helps to Promote Circulation 

    Escin (Esculin) is extracted from the tree (mostly the seeds) and is becoming very popular in 

phyto-medicine due to the clinical evidence of its effectiveness in the treatment of chronic venous 

insufficiency, varicose veins, and related vascular and circulatory disorders and is used in our Cellumend 


    This particular ingredient counters the effects of the shorter wavelengths of sunlight - which gives it the 

ability to absorb UV radiation but has excellent astringent and toning properties.

    It is normally only used as a topical application, although European medical practitioners have prescribed it 

internally - but due to the potential toxicity when taken internally it is not recommended.

    The action of this ingredient is to prevent vein fragility, which then also stops any leakage from the veins 

into the surrounding tissue, which would lead to swelling and edema.

    It is the triterpene glycoside mixture, aescin (escin), which contains the anti-exudative and vascular 

astringent and toning effect which is indicated to reduce the activity of lysosomal enzymes which is normally 

found in people with problems with their veins and circulation. This helps to reduce the breakdown of 

glycoacalyx (mucopolysaccharides) in the capillary walls.

    Because the veins are healthier and less "leaky", there is less leakage of low-molecular proteins, electrolytes

 and water out of the veins into the tissue.

    The aescin also acts as an antioxidant to help inhibit the enzymes collagenase and elastase which leads to 

healthier collagen and supportive skin structures and also seems to have some form of anti-inflammatory 


    Horse chestnut seed contains a 3-6% complex mixture of triterpene saponins which are collectively referred

 to as escin. REF 33 This includes the triterpene oligoglycosides escins, Ia, Ib, IIa, IIb, and IIIa REF 34 as 

well as acylated polyhydroxyoleanene triterpene oligoglycosides escins IIIb, IV, V, and VI and isoescins Ia, Ib,

 and V, and the sapogenols hippocaesculin and barringtogenol-C REF 35; flavonoids such as flavonol 

glycosides; tannins REF 36; quinones; sterols that includes stigmasterol, a- spinasterol, and b -sitosterol; as 

well as fatty acids, such as linolenic, palmitic, and stearic acids. REF 37 

    Other constituents found in the seed of the Horse Chestnut tree are 16-Desoxy-Barringtogenol, Acetic-Acid

 Alpha-Methyl-Beta-Hydroxybutyric-Acid, Angelic-Acid, Barringtogenol-C , Barringtogenol-D, 

Cryptoaescigenin, Cryptoaescin, Glucuronic-Acid, Protoaescigenin and Tiglic-Acid.

    Escin is a venotonic and anti-edematous ingredient and therefore helps to remove excess extra-cellular 


    It is an a saponin occurring in the seed of the Horse chestnut tree (Aesculus hippocastanum) and is 

chemically classed as a biological product.