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The Health Benefits of Genistein
Risun Bio-Tech Inc  Jun 12, 2016

The Health Benefits of Genistein 


Cancer protection

  The so-called phytoestrogens, like genistein and daidzein in soy, can bind to estrogen receptors and therefore interfere with the action of estrogen itself, a well-established risk factor for breast, ovarian and endometrial cancers. Although not all results are consistent, there is good evidence for protective influence of soy products against all three of these cancers. In addition, there have been many reports of preventive effects in the prostate.

Dry eyes

  Pure Genistein Could Offer Relief for Dry Eyes, According to Newly Published Patent, a press release sent in 2009 by DSM Nutritional Products, Inc. 

More than 20 million Americans suffer from the discomfort of dry eye syndrome (lacrimal keratoconjunctivitis), an ocular surface inflammation that develops from tear film failure. On October 9, 2008, the World Intellectual Property Organization published the pending patent by DSM Nutritional Products for genistein, which, according to the patent, when ingested, has been shown to provide a simple alternative to eye drops for maintaining healthy eyes. This discovery is based on a novel study in an animal model of induced dry eye syndrome. In this study, supplementation of the diet with genistein restored tear volume in the animals and increased the density of mucus-secreting goblet cells in an apparent dose-dependent manner. Goblet cells are responsible for the mucus layer in the conjunctiva of the eyelid. These findings suggest that genistein can potentially be used in dietary supplements to help maintain healthy eye structures and tear production, which would be a welcome alternative for millions of consumers who currently have little option but to use inconvenient eye-drop treatments. GeniVida, formerly known as BONISTEIN, is a branded pure non-soy genistein from DSM. It is available in both food- and pharmaceutical-grade and has an extensive, published safety package. GeniVida � is available in both crystalline and tablet-grade forms. DSM Nutritional Products is the world抯 premier ingredient supplier to producers of functional foods, beverages, and dietary supplements. The organization provides a solid platform for technological innovation and new product development. Utilizing its extensive resources, DSM Nutritional Products keeps its customers ahead of the ever-changing marketplace, anticipating customer needs as nutritional trends develop and customer demands evolve. For more information, please contact DSM Nutritional Products, Inc., Parsippany, NJ. 

Estrogen influence

  Many isoflavones have been shown to interact with animal and human estrogen receptors, causing effects in the body similar to those caused by the hormone estrogen or sometimes blocking the effects of certain receptors. Soy isoflavones also produce non-hormonal effects.

  Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women.

  Nutr Cancer. 2009. Department of Surgery, University of Missouri School of Medicine-Columbia, One Hospital Drive, Columbia, MO, USA.

  Thirty-four healthy premenopausal women were randomized to 40 mg or 140 mg isoflavones daily through one menstrual cycle. Breast specific and systemic estrogenic effects were assessed measuring the estrogenic marker complement (C)3 and changes in cytology, whereas methylation assessment of 5 cancer related genes was performed on intraductal specimens. Serum genistein significantly increased after consuming both isoflavone doses. Cytology did not significantly change at either isoflavone dose. Serum C3 levels posttreatment were inversely related to change in serum genistein in women consuming low but not high dose isoflavones. The RAR beta 2 hypermethylation increase posttreatment correlated with the posttreatment genistein level considering the entire group and those receiving high-dose isoflavones. At the low but not the high isoflavone dose, CCND2 hypermethylation increase correlated with posttreatment genistein levels. In summary, the inverse correlation between C3 and genistein suggests an antiestrogenic effect. Isoflavones induced dose-specific changes in RARbeta2 and CCND2 gene methylation, which correlated with genistein levels.                            

Inflammatory bowel disease, anti inflammatory effects 

  Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis.

  Eur J Nutr. 2009. Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, Germany.

  Inflammatory bowel disease in humans has a high incidence in Europe and the USA, whereas in East Asia, incidence has been historically low. The risk of IBD appears to increase in Asian immigrants adopting western lifestyles, suggesting a strong link of environmental/dietary factors in the development of IBD, most likely dietary factors. Exposure to high levels of isoflavones such as genistein in traditional East Asian diets has been associated with a decreased risk of developing breast cancer and may also be beneficial for the prevention of Inflammatory bowel disease. In this study, the effect of orally administered genistein on the inflammatory response in the TNBS-induced chronic colitis rat model was investigated. Our results may provide evidence that oral administration of genistein exerts beneficial anti-inflammatory effects in a rodent model of TNBS-induced chronic colitis.

Osteoporosis treatment

  Genistein supplements may be useful for bone health although many studies of long duration are needed.

  Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women.

  Osteoporos Int. 2009. Atteritano M, Mazzaferro S, Frisina A, Cannata ML, Bitto A, Macr� I, Frisina N, Buemi M. Department of Internal Medicine, University of Messina, Messina, Italy

  This study aimed at evaluating the effects of genistein (54 mg/day) on calcaneus and phalanges ultrasound (QUS) parameters and bone mineral density in osteopenic postmenopausal women. We concluded that it prevented bone loss in the osteopenic postmenopausal women and improves QUS parameters at the calcaneus and phalanges. The purpose of the study was to evaluate the effects of genistein (54 mg/die) on quantitative ultrasound (QUS) parameters of the calcaneus and hand phalange and on bone mineral density (BMD) in osteopenic postmenopausal women. One hundred thirty-eight women (age 49-67 years) were assigned to receive genistein or placebo. Bone status was assessed at baseline and after a 1- and 2-year treatment. At the end of the experimental period, genistein had significantly increased BMD in the femur and lumbar spine. Our study confirms that genistein prevented bone loss in the osteopenic postmenopausal women and it improves the calcaneus and phalanges ultrasound parameters.