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Pure Hot Sex Women and Animal Plant Osthole
Risun Bio-Tech Inc  Apr 19, 2016

                                                     Pure Hot Sex Women and Animal Plant Osthole

  Other name: cnidium monnieri; cnidium monnieri extract; cnidium;7-Methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one

  Specifications: Osthole 98%

  Appearance: White crystal powder.

  Test method: HPLC

  CAS NO.: 484-12-8

  Molecular formula: C15H16O3

  Molecular Weight: 244.29


  Health Benefits:

1.Increase sperm secretion, stimulate sexual desire and has aphrodisiac action;

2. Dry dampness and kills worms;

3. Expel cold and expel the wind;

4. Warm the kidney to strengthen yin;

5. Relieve asthma;

6. Antifungus, antivirus.

 

  Osthole (Ost), a natural coumarin derivative, has been shown to inhibit many pro-inflammatory mediators and block voltage-

gated Na+ channels. During inflammation, acidosis is an important pain inducer which activates nociceptors by gating

depolarizing cationic channels, such as acid-sensing ion channel 3 (ASIC3). The aim of this study was to examine the effects

of Ost on nucleus pulposus-evoked nociceptive responses and ASIC3 over-expression in the rat dorsal root ganglion, and to

investigate the possible mechanism.Radicular pain was generated with application of nucleus pulposus (NP) to nerve root.

Mechanical allodynia was evaluated using von Frey filaments with logarithmically incremental rigidity to calculate the 50%

probability thresholds for mechanical paw withdrawal. ASIC3 protein expression in dorsal root ganglions (DRGs) was

assessed with Western blot and immunohistochemistry. Membrane potential (MP) shift of DRG neurons induced by ASIC3-

sensitive acid (pH6.5) was determined by DiBAC(4) (3) fluorescence intensity (F.I.).The NP-evoked mechanical hyperalgesia

model showed allodynia for 3 weeks, and ASIC3 expression was up-regulated in DRG neurons, reaching peak on Day 7.

Epidural administration of Ost induced a remarkable and prolonged antinociceptive effect, accompanied by an inhibition of

over-expressed ASIC3 protein and of abnormal shift of MP. Amiloride (Ami), an antagonist of ASIC3, strengthened the

antinociceptive effect of Ost.Up-regulation of ASIC3 expression may be associated with NP-evoked mechanical hyperalgesia.

A single epidural injection of Ost decreased ASIC3 expression in DGR neurons and the pain in the NP-evoked mechanical

hyperalgesia model. Osthole may be of great benefit for preventing chronic pain status often seen in lumbar disc herniation

(LDH).