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Preventing Cancer---Grape Seed Extract
Risun Bio-Tech Inc  May 12, 2016

                                                                         Grape seed Extract

Product Name: Grape seed Extract

Botanical Source: Vitis Vinifera L.

Part Used: Seeds 

Appearance: Red-brown fine powder.

Specification: 95% Proanthocyanidins; 85% Polyphenols

Test Method: UV

Pharmacologic Activity

Human case reports and results from laboratory and animal studies show that Grape Seed Powdered Extract may be useful to treat heart diseases such as high blood pressure and high cholesterol. By limiting lipid oxidation, phenolics in grape seeds may reduce risk of heart disease, such as by inhibiting platelet aggregation and reducing inflammation. While such studies are promising, more research including long-term studies in humans is needed to confirm initial findings.A polyphenol contained in grape seeds is resveratrol which may interfere with cancer cell growth and proliferation, as well as induce apoptosis, among a variety of potential chemopreventive effects.

Biological Activity

Preliminary research shows that Grape Seed Powdered Extract may have other possible anti-disease properties, such as in laboratory models of: 1) wound healing—grape seed proanthocyanidins induced vascular endothelial growth factor and accelerated healing of injured skin in mice. 2) tooth decay --seed phenolics may inhibit oral sugar metabolism and retard growth of certain bacteria causing dental caries.  3) osteoporosis -- grape seed extracts enhanced bone density and strength in experimental animals. 4) skin cancer -- grape seed proanthocyanidins decreased tumor numbers and reduced the malignancy of papillomas. 5) ultraviolet damage to skin—dietary proanthocyanidins may protect against carcinogenesis and provide supplementation for sunscreen protection.

The leaves and fruit of the grape have been used medicinally since ancient Greece. Today, grape seed extract is used as a folk or traditional remedy for conditions related to the heart and blood vessels, such as atherosclerosis (hardening of the arteries), high blood pressure, high cholesterol, and poor circulation; complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration (which can cause blindness); swelling after an injury or surgery; cancer prevention; and wound healing.

The grape seeds used to produce grape seed extract are generally obtained from wine manufacturers. Grape seed extract is available in capsule and tablet forms.

What the Science Says

Studies have found that some compounds in grape seed extract may be effective in relieving symptoms of chronic venous insufficiency (when veins have problems sending blood from the legs back to the heart) and reducing edema (swelling) after an injury or surgery.

Small randomized trials have found beneficial effects of grape seed extract for diabetic retinopathy (an eye problem caused by diabetes) and for vascular fragility (weakness in small blood vessels). Larger trials are needed to confirm these findings.

Grape seed extract contains antioxidants, which help prevent cell damage caused by free radicals (highly reactive molecules that can damage cell function). Preliminary studies have shown some beneficial antioxidant effects; however, more research is needed.

A study funded by the National Cancer Institute (NCI) found that grape seed extract did not reduce the hardening of breast tissue that can occur after radiation therapy for breast cancer.

NCI is also funding studies to evaluate whether grape seed extract is effective in preventing breast cancer in postmenopausal women and prostate cancer.

NCCIH is studying whether the action of grape seed extract and its components may benefit the heart or help prevent cognitive decline, Alzheimer's disease, and other brain disorders. Another study is investigating the effects of grape seed extract on colon cancer.