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Nattokinase--- the Therapeutic Effects on Vascular and Heart Disease
Risun Bio-Tech Inc  Apr 21, 2016


Other name: Nattoesse Haruno-Ogawa


1. Nattokinase 20000fu/g

2. Nattokinase12000fu/g

Appearance: Light yellow to Milk white fine powder.

Test method: HPLC/UV 

health benefits:

  Nattokinase (pronounced nat-oh-KY-nase) is a powerful enzyme extracted and purified from

a traditional Japanese functional food called natto. Natto is a cheese-like product made

from boiled or steamed soybeans fermented with beneficial bacteria known as Bacillus

subtilis or Bacillus natto. Natto has a characteristically slippery consistency and strong

aroma, but it is generally tasteless. Although a variety of soy-based products contain

active enzymes, only natto preparations are known to produce nattokinase.
   Natto has been an important part of the Japanese diet for over a century, and is known

for its therapeutic effects on vascular and heart disease. Nattokinase is widely recognized

for its potent fibrinolytic properties, and can dissolve dangerous blood clots through a

variety of mechanisms. In this respect, nattokinase acts much like our body’s own

naturally-produced fibrin-degrading enzyme known as plasmin. Human plasmin is found in the

blood and serves as a defense system against hazardous blood clots associated with

cardiovascular disease and stroke. Nattokinase also shares a similar clot-dissolving

mechanism with other commonly-used thrombolytic drugs. However, nattokinase is much cheaper

and carries a lower risk of side effects.
  While natto may not be readily available in all regions, its active ingredient

nattokinase can be found in the form of a dietary supplement. Since traditional natto is an

acquired taste, some people prefer the supplemental form of nattokinase, especially since

it offers similar benefits。

  Health Benefits of Nattokinase
Nattokinase’s ability to break down fibrin as well as increase blood flow and tissue

oxygen levels are the main mechanisms which allow it to reduce the risk of cardiac disease.
  Fibrinolytic and Anti-Thrombotic Activity of Nattokinase
Although the human body produces a number of enzymes that promote the growth of a thrombus

(blood clot), the only natural enzyme that works to breaks down the thrombus is called

plasmin. Since nattokinase is similar in molecular stru However, in addition to having

direct fibrinolytic actions (like plasmin),nattokinase can also increase the body’s own

production of plasmin, as well as several other agents that assist in dissolving blood

clots (e.g., urokinase).
Nattokinase has been shown to be effective for preventing the unwanted formation of blood

clots in the legs (DVT) after a 7-8 hour airplane flight. In light of the data supporting

nattokinase, Dr. Martin Milner from the Center for Natural Medicine in Portland has stated

that nattokinase is not only highly effective in breaking down a thrombus, but seems to be

even more potent than the traditional “clot-busting” drugs (i.e., Tissue plasminogen

activatortPA). In fact, nattokinase is considered to be the most potent fibrinolytic enzyme

ever discovered.1
According to Dr. Milner, drugs like tPA can sometimes fail to dissolve the clot, even

though they are generally effective for this condition. This is because clots that reach a

certain stage tend to become more resistant to traditional drugs. Fortunately, nattokinase

can dissolve these resistant clots when taken orally at 100 mg/day.
Since it takes 4-6 hours for half of the nattokinase taken to be broken down, its

therapeutic effects can last even after the patient stops taking nattokinase. This means

that the actions of nattokinase last longer than most clot-dissolving drugs available on

the market.As a result, nattokinase not only dissolves existing clots, but can also help

prevent future clots from developing.
Since circulating amounts of both FDP (fibrin degradation products) and EFA (euglobulin

fibrinolytic activity) are known to rise when clots are being dissolved, these compounds

can be used to monitor nattokinase’s lingering effects. After measuring the EFA and FDP

levels, researchers found that the activity of nattokinase can last for 8 to 12 hours.

  Cardiovascular Health Benefits
In addition to its ability to fight stroke, nattokinase has a number of other actions that

benefit the cardiovascular system. For example, nattokinase has been shown to reduce blood

pressure by inhibiting the angiotensin II converting enzyme (ACE). Reductions in blood

pressure are well known to decrease your risk of cardiovascular disease.
Nattokinase has also shown promise for the treatment of hyperlipidemia.24 Nattokinase has

also been suggested for preventing atherosclerosis and it’s more general form,

arteriosclerosis, Atherosclerosis is a disorder in which the arterial walls harden and


  Immunomodulatory Effects
A 2012 study conducted among mice has demonstrated that nattokinase is able to enhance the

immune function of macrophages. Macrophages are a type of white blood cell responsible for

engulfing foreign substances that may be threatening to the body. As such, macrophages act

as a security system, alerting the immune system to foreign invaders.
There is also some evidence that suggests that the active bacteria found in natto may

indirectly induce the production of cytokines in the intestinal mucosa. This is important

because cytokines (e.g., interleukins, interferons, and growth factors) act as protein

messengers, allowing immune cells to communicate with each other in order to mount an

appropriate immune response.
Given the promising results of this animal study, it is expected that further human studies

will be designed to demonstrate nattokinase’s beneficial effects on the immune system.

  Additional Health Benefits
Most people who research nattokinase are amazed by the sheer number of potential health

benefits it is associated with. For instance, it has been suggested that nattokinase may

benefit conditions like diabetes, which often leads to excess platelet aggregation.

Nattokinase may also be beneficial for senile dementia, which is characterized by cerebral

thrombi formation as well as poor circulation/blood supply. Further potential health

benefits of nattokinase include reducing chronic migraine, fibromyalgia, chronic fatigue

syndrome, Lyme disease, and menstrual cramps.16Some studies even suggest that natto may

display activity against tumor growth.
A 2006 study demonstrated that nattokinase has helpful effects on a common eye condition

called Posterior Vitreous Detachment (PVD). This condition occurs frequently with old age

and involves a decrease in the volume of ocular gel that makes up nearly 70% of the liquid

in the eye. This causes a decreased blood supply to the retina and interferes with normal

Nattokinase has also shown potential for use in preventing and alleviating Alzheimer’s

disease. This illness involves the development of amyloid fibrils, which are clumps of

fibrous protein that form in the brain and other areas of the body, causing various

deleterious effects. Research conducted on nattokinase shows that it possesses amyloid-

degrading properties, thus warranting further study for this indication.
Nattokinase also shows promise as a treatment for sciatic nerve injury, since it suppresses

injury-induced fibrin production and reduces inflammatory cytokines. Nattokinase also

enhances nerve myelination and contributes to nerve regeneration, which means that it may

be beneficial for a variety of disorders of the nervous system.