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How the Nattokinase Produce and Apply?
Risun Bio-Tech Inc  May 31, 2016

How the Nattokinase Produce and Apply


  Nattokinase (NK, also known as subtilisin NAT) (EC 3.4.21.62) is one of the most considerable 

extracellular enzymes produced by Bacillus subtilis natto. The main interest about this enzyme 

is due to its direct fibrinolytic activity. Being stable enough in the gastrointestinal tract 

makes this enzyme a useful agent for the oral thrombolytic therapy. Thus, NK is regarded as a 

valuable dietary supplement or nutraceutical. Proven safety and ease of mass production are 

other advantages of this enzyme. In addition to these valuable advantages, there are other 

applications attributed to NK including treatment of hypertension, Alzheimer's disease, and 

vitreoretinal disorders. This review tends to bring a brief description about this valuable 

enzyme and summarizes the various biotechnological approaches used in its production, recovery, 

and purification. Some of the most important applications of NK, as well as its future 

prospects, are also discussed.